Why Up the Nose?

About 96% of people taking oral medications said they were dissatisfied with at least one aspect of their medication.*
*In a survey of 3930 US patients using oral acute prescription medication for migraine attacks.
3 key limitations of some pills and dissolvable tablets
They take too long
- To work quickly, oral medications like pills and tablets rely on a digestive system that’s readily able to absorb medication. And often, nausea, vomiting, and other GI-related disorders and symptoms can accompany a migraine attack and delay absorption.
Trudhesa™ delivers medication to the upper nasal space where it can be quickly absorbed and quickly go to work.
3 key limitations of some pills and dissolvable tablets

Actor Portrayal
They don’t last long enough
- In a survey of people who take an oral acute prescription medication, nearly 2 out of 5 reported relief wore off just 24 hours after taking their medication. More than half said they continue to have moderate to severe disability.*
For many, Trudhesa can provide relief that lasts up to 2 days with a single dose, time after time.

They have time limits on dosing
Many oral medications need to be taken within the first 60 minutes of a migraine attack to be most effective. But you know that’s not always possible.
Trudhesa is proven to work on migraine symptoms even when taken late into a migraine attack, so you can take it on your terms.†
Trudhesa may be right for you if:
You need relief that’s Speedy for rapid-onset migraine attacks
- You have sudden, unpredictable migraine attacks that outlast your oral medication
- Your migraine attacks are often accompanied by nausea, vomiting, or other GI issues
You need Steady, long-lasting relief
- Your migraine pain returns within 24 hours of taking
your oral medication - Inconsistent relief makes you worry about your
migraine attack roaring back
You need reliable, at-the-ready relief, even when taken late into a migraine attack
- Sometimes you can’t take your medication within an hour of when a migraine attack starts
- Your go-to migraine medication works sometimes but not others


Goes where migraine pills don’t. Does what migraine pills can’t.
Only Trudhesa uses POD® technology to deliver proven medication to the upper nasal space.
If you’re not getting the relief you need, and you want a medication that can work:
Quickly, and for a long time
Without having to be taken orally
Even when taken late into an attack
When attacks just won’t go away
Then Be Direct with your healthcare provider. Ask about Trudhesa.

Give it a Try!
84% of people either agreed or strongly agreed Trudhesa was easy to use‡
*In a survey of 3930 people using oral acute prescription medication for migraine attacks.
†Exploratory efficacy outcomes are based on patient reports and post hoc analyses from a phase 3, open-label safety study of Trudhesa.
‡Results were from a poststudy questionnaire, which asked 354 people to rate their experience with Trudhesa compared to their best usual care at baseline. The results were patient-reported and not validated.
