Why Up The Nose | Trudhesa® (dihydroergotamine mesylate) nasal spray

Goes where migraine pills don’t.

Only Trudhesa^® uses POD^® technology to deliver proven medication to the upper nasal space.

Please follow complete Instructions for Use, provided with the product.

TITLE: WHY THE UPPER NASAL SPACE MAY BE THE IDEAL ROUTE TO RELIEF

VOICE OVER: The upper nasal space is a unique and underutilized environment for drug delivery. The ciliated olfactory epithelium in this richly vascularized space makes it ideal for rapid absorption into the systemic circulation, potentially leading to a faster response than oral medications. Potential benefits of delivery to this space also include the reduction of drug-related adverse effects and potential avoidance of delayed absorption in the GI tract and first-pass metabolism in the liver.

Traditionally, nasal drug administration has focused on delivery to the lower nasal space, which is associated with significant drug loss from the nose with existing delivery systems, which may lead to variability in absorption. In addition, deep inspiration associated with existing systems can collapse the nasal valve essentially blocking access to the vascular rich upper nasal space.

The mucosal layer in the upper nasal space tends to be more permeable and stable than the lower nasal cavity, permitting consistent, faster and more extensive absorption of drug into the underlying vasculature with less mucociliary clearance.

ONSCREEN: WHY THE UPPER NASAL SPACE MAY BE THE IDEAL ROUTE TO RELIEF

84%

of people either agreed or strongly agreed Trudhesa was easy to use.^‡

96%

of people taking oral medications said they were dissatisfied with at least one aspect of their medication.*

*In a survey of 3930 US patients using oral acute prescription medication for migraine attacks.

3 key limitations of some pills and dissolvable tablets

To work quickly, oral medications like pills and tablets rely on a digestive system that’s readily able to absorb medication. And often, nausea, vomiting, and other GI-related disorders and symptoms can accompany a migraine attack and delay absorption.

Trudhesa™ delivers medication to the upper nasal space where it can be quickly absorbed and quickly go to work.

In a survey of people who take an oral acute prescription medication, nearly 2 out of 5 reported relief wore off just 24 hours after taking their medication. More than half said they continue to have moderate to severe disability.*

For many, Trudhesa can provide relief that lasts up to 2 days with a single dose, time after time.

Many oral medications need to be taken within the first 60 minutes of a migraine attack to be most effective. But you know that’s not always possible.

Trudhesa is proven to work on migraine symptoms even when taken late into a migraine attack, so you can take it on your terms.^†

Trudhesa may be right for you if:

You need relief from rapid-onset migraine attacks

You have sudden, unpredictable migraine attacks that outlast your oral medication.
Your migraine attacks are often accompanied by nausea, vomiting, or other GI issues.

You need long-lasting relief

Your migraine pain returns within 24 hours of taking your oral medication.
Inconsistent relief makes you worry about your migraine attack roaring back.

You need relief, even when taken late into a migraine attack

Sometimes you can’t take your medication within an hour of when a migraine attack starts.
Your go-to migraine medication works sometimes but not others.

*In a survey of 3930 US patients using oral acute prescription medication for migraine attacks.

^†Exploratory efficacy outcomes are based on patient reports and post hoc analyses from a phase 3, open-label safety study of Trudhesa.

^‡Results were from a poststudy questionnaire, which asked 354 people to rate their experience with Trudhesa compared to their best usual care at baseline. The results were patient-reported and not validated.