How to Use

Precision Olfactory Delivery (POD®) technology sends medicine directly to the upper nasal space so you don’t have to worry about it dripping down onto your upper lip or the back of your throat. And unlike other migraine nasal sprays, you don’t have to tilt your head or coordinate sniffing and inhaling. Trudhesa™ does the work for you.*

*People in a study noted that Trudhesa had less dripping (32% vs 77%), less post-nasal drip (32% vs 56%), and was easier to use (71% vs 53%) than a previous DHE nasal spray product.

Before using Trudhesa, watch this quick how-to video


Please follow complete Instructions for Use, provided with the product.

Watch How to Use video. Still representation of an instructional video with a person holding Trudhesa® sitting in a room with words "Be Direct"

TITLE: Be Direct

VOICEOVER: Ok, are you having a migraine attack? Time to be direct. Let’s go. De-box and determine that everything is in good shape. It looks good to me. Next, you install. Just be careful, it can be a little sharp. Well, R is for ready. You ready the POD® by priming it. You press firmly 4 times. This is very important. Looks like it’s ready. Now you engage the POD to the nose, and you press like you’re priming. It’s nice and gentle. Now complete your dose in the other nostril. Last step, T is for toss. Get rid of it, throw it away, you do not need it. You only use it once. That’s it! You have a migraine attack? Be direct. And don’t forget to check out these. Stay tuned for the Important Safety Information. For complete administration information, please see the Instructions for Use sheet that comes in each box of Trudhesa.

Ready for Trudhesa? Just be DIRECT


All you need to remember is Be DIRECT.

Please follow complete Instructions for Use, provided with the product.

Determine everything is
good to go

Install vial and POD
together

Ready the POD by priming

Engage POD to nose

Complete your dose with
one spray per nostril.

Toss as it can only be
used once.

Getting Trudhesa

Actor portrayal of Trudhesa® patient smiling with short hair,  looking to the left
Actor portrayal of Trudhesa® patient smiling with short hair,  looking to the left