FAQs

Trudhesa is a prescription medicine used for the acute treatment of migraine with or without aura in adults.

• Trudhesa is not used to prevent migraine
• Trudhesa is not used to treat other types of headaches such as hemiplegic (that make you unable to move on one side of your body) or basilar (rare form of migraine with aura) migraines

It is not known if Trudhesa is safe and effective in children.

Trudhesa might be right for you if:

• You have rapid-onset migraine attacks
• Your migraine attacks come back within 24 hours after taking medication
• You have nausea, vomiting, or other GI-related issues, during or in between migraine attacks
• You need relief that starts quickly and lasts for days, time after time

If any of these apply, ask your HCP if Trudhesa may be right for you. If you’re interested in Trudhesa and want your HCP to know more about it, download Trudhesa 101 for your HCP

Trudhesa is a unique combination of proven medication and one-of-a-kind delivery for pain freedom that can start quickly and last for days, time after time. The medication in Trudhesa is called DHE or dihydroergotamine mesylate, and it’s been used for years by specialists to work when nothing else will. Trudhesa and its Precision Olfactory Delivery (POD®) is designed to gently and consistently deliver the right amount of medication to the upper nasal space. This area of the nose is rich in blood vessels so medication can be quickly absorbed into your circulation.

Before taking Trudhesa in conjunction with any other medication, be sure to consult with your HCP as to whether or not they can be taken together.

If you’re like many people in the Trudhesa study, you may be pain free within 2 hours (some experienced relief in as little as 15 minutes) and remain pain free for as long as 2 days. All with a single dose. Trudhesa was also shown to provide reliable relief. And to work whether it’s taken early in a migraine attack or several hours into one. *Exploratory efficacy outcomes are based on patient reports and post hoc analyses from a phase 3, open-label safety study of Trudhesa.

In the Trudhesa study, many people reported getting freedom from migraine symptoms such as pain or their most bothersome symptom within 2 hours, while some reported getting relief in as soon as 15 minutes. *Exploratory efficacy outcomes are based on patient reports and post hoc analyses from a phase 3, open-label safety study of Trudhesa.

POD is designed to do the work for you. Before using Trudhesa, download the Instructions for use. Please also watch the "Be Direct" Video, which takes you through the process. For complete dosing and administration information, please see the Trudhesa Medication Guide.

The medication in Trudhesa is called dihydroergotamine mesylate or DHE. It has been used for over 70 years by specialists for how quickly it works, how long it works, and how reliably it relieves migraine attacks.

Do not take Trudhesa with strong CYP3A4 inhibitors.

Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Trudhesa) and strong CYP3A4 inhibitors (such as protease inhibitors and macrolide antibiotics) have been reported rarely. As a result, these medications should not be taken together.

Tell your HCP about all the medications you are taking.

Do not take Trudhesa if you have taken any of the following medicines in the last 24 hours: sumatriptan, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, ergotamine, or ergotamine-type medicines.

For a complete list of medications that may be harmful if taken together with Trudhesa, please refer to the Medication Guide.

If you have commercial insurance, you will be automatically enrolled in the Trudhesa Direct Savings Program and will receive Trudhesa for as little as $0 per prescription.* Copay savings will be automatically applied, starting with the very first prescription, without the need to carry a copay card.

*If you have commercial medical insurance, your first prescription is guaranteed for $0 per prescription.

Do not use Trudhesa if you are pregnant, nursing, or plan to become pregnant.

Trudhesa needs to be prescribed by your HCP. Many headache specialists, neurologists, and primary care physicians will be familiar with Trudhesa. If not, however, you can download Trudhesa 101 for your HCP. It details all the vital information they need to know about Trudhesa that can help you both decide if Trudhesa is right for you.

Trudhesa was reported to provide reliable relief of migraine symptoms in some people, whether it was taken early in a migraine attack or several hours into one.

Like most medical devices, POD is made up of multiple parts and currently cannot be recycled. However, the outer plastic case can be recycled along with all cardboard shipping and storage boxes that are identified with the appropriate recycling symbol.