Words 'Migraine can affect the gut. Maybe your migraine med should avoid the gut'
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About 96% of people taking oral medications said they were dissatisfied with at least one aspect of their medication.*

*In a survey of 3930 US patients using oral acute prescription medication for migraine attacks.

3 key limitations of some pills and dissolvable tablets
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They take too long

To work quickly, oral medications like pills and tablets rely on a digestive system that’s readily able to absorb medication. And often, nausea, vomiting, and other GI-related disorders and symptoms can accompany a migraine attack and delay absorption.

Trudhesa delivers medication to the upper nasal space where it can be quickly absorbed and quickly go to work.

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They don’t last long enough

In a survey of people who take an oral acute prescription medication, nearly 2 out of 5 reported relief wore off just 24 hours after taking their medication. More than half said they continue to have moderate to severe disability.*

For many, Trudhesa can provide relief that lasts up to 2 days with a single dose, time after time.

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They have time limits on dosing

Many oral medications need to be taken within the first 60 minutes of a migraine attack to be most effective. But you know that’s not always possible.

Trudhesa is proven to work on migraine symptoms even when taken late into a migraine attack, so you can take it on your terms.

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Trudhesa may be right for you if:

You need relief that’s speedy for rapid-onset migraine attacks

  • You have sudden, unpredictable migraine attacks that outlast your oral medication
  • Your migraine attacks are often accompanied by nausea, vomiting, or other GI issues

You need steady, long-lasting relief

  • Your migraine pain returns within 24 hours of taking your oral medication
  • Inconsistent relief makes you worry about your migraine attack roaring back
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You need reliable, at-the-ready relief, even when taken late into a migraine attack

  • Sometimes you can’t take your medication within an hour of when a migraine attack starts
  • Your go-to migraine medication works sometimes but not others
Goes where migraine pills don’t. Does what migraine pills can’t.
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Only Trudhesa uses POD® technology to deliver proven medication to the upper nasal space.
If you’re not getting the relief you need, and you want a medication that can work:
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Quickly, and for a long time
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Without having to be taken orally
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Even when taken late into an attack
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When attacks just won’t go away

Then Be Direct with your healthcare provider. Ask about Trudhesa.

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Give it a try!

84% of people either agreed or strongly agreed Trudhesa was easy to use

  • *In a survey of 3930 people using oral acute prescription medication for migraine attacks.
  • Exploratory efficacy outcomes are based on patient reports and post hoc analyses from a phase 3, open-label safety study of Trudhesa.
  • Results were from a poststudy questionnaire, which asked 354 people to rate their experience with Trudhesa compared to their best usual care at baseline. The results were patient-reported and not validated.
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Trudhesa Difference

Serious or potentially life-threatening reductions in blood flow to the brain or extremities due to interactions between dihydroergotamine (the active ingredient in Trudhesa) and strong CYP3A4 inhibitors (such as protease inhibitors and macrolide antibiotics) have been reported rarely. As a result, these medications should not be taken together.
Trudhesa is used to treat an active migraine headache with or without aura in adults. Do not use Trudhesa to prevent migraine when you have no symptoms. It is not known if Trudhesa is safe and effective in children.
Do not use Trudhesa if you:
  • Have any disease affecting your heart, arteries, or blood circulation
  • Are taking certain anti-HIV medications known as protease inhibitors (such as ritonavir or nelfinavir)
  • Are taking a macrolide antibiotic such as clarithromycin or erythromycin
  • Are taking certain antifungals such as ketoconazole or itraconazole
  • Have taken certain medications such as triptans or ergot-type medications for the treatment or prevention of migraine within the last 24 hours
  • Have taken any medications that constrict your blood vessels or raise your blood pressure
  • Have severe liver or kidney disease
  • Are allergic to ergotamine or dihydroergotamine
Before taking Trudhesa, tell your doctor if:
  • You have high blood pressure, chest pain, shortness of breath, heart disease; or risk factors for heart disease (such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease or you are postmenopausal, or male over 40); or problems with blood circulation in your arms, legs, fingers, or toes.
  • You have or had any disease of the liver or kidney.
  • You are taking any prescription or over-the-counter medications, including vitamins or herbal supplements.
  • You are pregnant, planning to become pregnant or are nursing, or have ever stopped medication due to an allergy or bad reaction.
  • This headache is different from your usual migraine attacks.

The use of Trudhesa should not exceed dosing guidelines and should not be used on a daily basis.

Serious cardiac (heart) events, including some that have been fatal, have occurred following the use of dihydroergotamine mesylate, particularly with dihydroergotamine for injection, but are extremely rare.

You may experience some nasal congestion or irritation, altered sense of taste, sore throat, nausea, vomiting, dizziness, and fatigue after using Trudhesa.

Contact your doctor immediately if you experience:

  • Numbness or tingling in your fingers and toes
  • Severe tightness, pain, pressure, heaviness, or discomfort in your chest
  • Muscle pain or cramps in your arms or legs
  • Cold feeling or color changes in 1 or both legs or feet
  • Sudden weakness
  • Slurred speech
  • Swelling or itching

The risk information provided here is not comprehensive. To learn more, talk about Trudhesa with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at www.trudhesa.com or 1-800-555-DRUG. You can also call 1-833-TRUDHESA (1-833-878-3437) for additional information.